USMLE 1 and 2 (A rated Q&A)

Histones are rich in which 2 amino acids? - Lysine Arginine What histone protein is responsible for binding to the nucleosome and to the "linker" DNA thereby stabilizing the chromatin fiber? - H1 When does DNA and histone synthesis occur in the cell cycle? - S-phase Will the following be incr...

Sensitivity - TP / (TP + FN) Specificity - TN / (TN + TP) Positive Predictive Value - TP / (TP + FP) Negative Predictive Value - TN / (FN + TN) Incidence Rate - # of new cases in a certain time period / population that is at risk during that time period This looks at new incidences occurring d...

What gland is found in the muscular triangle of the neck? - Thyroid gland Is an afferent or efferent pupillary defect described as B/L pupillary constriction when light is shined in the unaffected eye and B/L paradoxical dilation when light is shined in the affected eye? - Afferent pupillary defe...

Chromatin structure - Negatively charged DNA loops twice around histone octamer (2 each of the positively charged H2A, H2B, H3, and H4) to form nucleosome bead. H1 ties nucleosomes together in a string. (Think of "beads on a string"; H1 is the only histone that is not in the nucleosome core.) I...

often precedes squamous cell carcinoma - actinic keratosis primary adrenocortical deficiency - Addison's disease polyostotic fibrous dysplasia, precocious puberty, cafe-au-lait spots, short stature, young girls - diagnosis? - Albright's syndrome hereditary nephritis with nerve deafness - Alpor...

Bacterial Structures: Peptidoglycan - Gives rigid support, protects against osmotic pressure; Sugar backbone w/ cross-linked peptide side chains. (function; chemical composition) Bacterial Structures: Cell wall / cell membrane (G+'s) - Major surface Ag; Peptidoglycan for support. Teichoic acid i...

What are the major functions of the α1 receptor? - Increase vascular smooth muscle contraction, increase pupillary dilator muscle contraction (mydriasis), increase intestinal and bladder sphincter muscle contraction What are the major functions of the α2 receptor? - Decrease sympathetic outflow...

A 38-year-old man presents to the emergency department due to seizures that started earlier that day, as reported by his sister. He adds that his vision is also blurry. The patient says he has never traveled outside of the United States. Physical examination reveals several enlarged cervical lymph...

What gland is found in the muscular triangle of the neck? - Thyroid gland Is an afferent or efferent pupillary defect described as B/L pupillary constriction when light is shined in the unaffected eye and B/L paradoxical dilation when light is shined in the affected eye? - Afferent pupillary defe...

Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) - Budd-Chiari syndrome Achilles tendon xanthoma - Familial hypercholesterolemia Adrenal hemorrhage, hypotension, DIC - Waterhouse-Friderichsen syndrome (meningococcemia) Arachnodactyly, lens dislocation, aortic dissectio...

What gland is found in the muscular triangle of the neck? - Thyroid gland Is an afferent or efferent pupillary defect described as B/L pupillary constriction when light is shined in the unaffected eye and B/L paradoxical dilation when light is shined in the affected eye? - Afferent pupillary defe...

pregnant with active HBV - tx newborn with HBIG and HBV vaccine Beck's triad for tamponade - hypotension, JVD, muffled heart sounds (also pulsus paradoxus). Electrical alternans subarachnoid hemorrhage - increased ADH and BNP --> hyponatremia. Tx - water restriction coccidioidomycosis - SW U...

Argatroban - Direct thrombin inhibitor Contraindicated in Renal Insuficiency Indicated in Liver Disease Fondaparinux - Factor Xa inhibitor Contraindicated in Liver failure Indicated in Kidney Failure Conditions associated to ITP - Lymphoma, leukemia, HIV, HCV, EBV, SLE, alcohol use, chemothera...

Classic EKG finding in atrial flutter - "Sawtooth" p waves Definition of unstable angina - Angina that is new, is worsening, or occurs at rest Antihypertensive for a diabetic patient with proteinuria - ACEI Beck's triad for cardiac tamponade - Hypotension, distant heart sounds, and JVD Drugs ...