Genome Wide Association Studies Essay
The advent of GWAS has been driven by the relevant genome projects paralleled with rapid technological advancements. The GWAS provide a framework and methodology to further understand the genetic variants involved in common and complex diseases, such as diabetes type 2. Prior to GWAS, novel approaches such as linkage analysis was used to determine SNP’s. There has been a degree of criticism to the relevance of the GWAS in relation to the money invested in it. A major principle for the basis of GWAS is population based linkage disequilibrium (LD).