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Newest Principles of Development summaries
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15. Genomic Imprinting
- Class notes • 8 pages • 2020
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- To give an overview of genomic imprinting, when it is initiated and how imprinting disorders can arise
- Describe key events in X-inactivation including the role of the Xist non-coding RNA
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8. Building Bodies
- Class notes • 7 pages • 2020
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- Describe the different types of animal body symmetry and the main body axes of bilaterally symmetrical animals.
- Describe the features that define diploblasts versus triploblasts.
- Describe the features that define protostomes versus deuterostomes.
- Understand the importance of the Ediacaran and Cambrian fauna in animal evolution.	
- Describe the common features of phylotypic stage chordate embryos.
- Discuss the evidence indicating that Pax6 is a conserved regulator of eye development. 
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6. Limb Development
- Class notes • 7 pages • 2020
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- Identify the important signalling centres in the developing limb bud and describe the experiments that identified these centres and demonstrated their importance.
- Describe the experimental evidence for the role of FGF signalling in limb bud outgrowth
- Describe the experimental evidence that shows that Shh acts as a morphogen to pattern the anterior-posterior axis of the limb bud.
- Describe how the important signalling centres in the limb bud co-ordinately regulate pattern formation in the ...
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1. Segmentation Genes
- Class notes • 7 pages • 2020
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-Describe the hierarchy of gene activity that regulates Drosophila segmentation
-Distinguish and explain methods used to investigate protein vs mRNA expression
-Describe the syncytial nature of the early stages of fly development and understand its significance.
-Understand and describe at the molecular level how the Gap genes regulate the expression of Eve stripe 2
-Make predictions about segment polarity gene expression in a pair-rule mutant embryo or about pair-rule gene expression in a Gap m...
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9. Backs & Fronts
- Class notes • 7 pages • 2020
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- Discuss the evidence supporting a role for tinman homologues in heart development
- Discuss the anatomical and molecular evidence supporting the theory of dorsoventral axis inversion during the evolution of protostome and deuterostome lineages.
- Describe the conserved features of Hox gene cluster organisation.
- Appreciate and discuss how changes in the expression and activity of Hox genes have contributed to changes in anatomy during animal evolution.
- Draw conclusions regarding the molecul...
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4. Neurogenesis
- Class notes • 6 pages • 2020
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- Describe the experimental evidence supporting a conserved pathway for regulating neurogenesis in animals
- Discuss the conserved function of proneural genes in neurogenesis
- Discuss the conserved function of neurogenic genes in neurogenesis
- Describe the role of lateral inhibition in selecting neural precursors
- Describe the conserved role of notch-delta signalling in mediating lateral inhibition
- Appreciate and discuss the distinct processes of neural induction, neurogenesis and neurulati...
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3. Neural Induction
- Class notes • 6 pages • 2020
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- Appreciate and describe the molecular mechanisms underlying neural induction
- Describe TGF-beta (TGF-β) signal transduction and the differences between the BMP versus nodal pathways
- Discuss the experiments that demonstrate a role for BMP antagonists in vertebrate neural induction
- Describe how antisense morpholino oligos can be used to inhibit gene function
- Appreciate and describe the differences between the processes of neural induction versus neurogenesis
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