Gms 6504 exam 2024 Samenvattingen, Notities en Examens
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GMS 6504 MODULE 1-3 Exam 1 Questions with 100% Correct Answers | Latest Version 2024 | Expert Verified | Ace the Test
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GMS 6504 MODULE 1-3 Exam 1 Questions with 100% 
Correct Answers | Latest Version 2024 | Expert 
Verified | Ace the Test
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GMS 6504 MODULE 1-3 Exam 1 (2024) Questions With Complete
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GMS 6504 MODULE 1-3 Exam 1 (2024) Questions With Complete
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GMS 6504 Exam Questions and Answers 100% Correct!!
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Lipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 
1. mass greater than 500 Da 
2. highly lipophilic - logP > 5 
3. more than 5 hydrogen bond donors 
4. more than 10 hydrogen bond acceptors 
 
Partition coefficient - ANSWER-p = C(octanol)/C(water) 
- ratio of the equilibrium concentrations of dissolved substance in a two-phase system containing two largely immiscible solvents (water & octanol) 
- Log10(P) 
 
Improved Lipinski Parameters - ANSWER-1. Partition...
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GMS 6504 MODULE 1-3 Exam 1 Questions and Answers 100% Correct!!
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What are System Independent Parameters? - ANSWER-Affinity 
Efficacy 
 
What are the parts of a system that are identified as System Dependent Parameters? - ANSWER-Number of receptors 
Cellular machinery 
Presence of other drugs 
- Competitive 
- Noncompetitive 
 
Affinity is - ANSWER-Thermokinetic propensity of drug to bind to receptor 
 
Based largely on ΔG 
 
Efficacy is - ANSWER-Magnitude of change of receptor shape/function upon drug binding 
 
Based on atom/atom interactions 
 
What i...
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