GWAS Study guides, Class notes & Summaries

Dit is een samenvatting van de colleges van Experimental Immunology deel 2 en bevat: 1. Epigenetic regulation of macrophages (MS) 2. Mass cytometry 3. Intravital microscopy 4. SNP in GWAS 5. GWAS and mouse models for IBD 6. Gene expression 7. Methods to inhibit or induce gene expression

The advent of GWAS has been driven by the relevant genome projects paralleled with rapid technological advancements. The GWAS provide a framework and methodology to further understand the genetic variants involved in common and complex diseases, such as diabetes type 2. Prior to GWAS, novel approaches such as linkage analysis was used to determine SNP’s. There has been a degree of criticism to the relevance of the GWAS in relation to the money invested in it. A major principle for the basis of...

UCL BIOL2005 Genetic Systems; 3 mouse lectures - mouse genetics, mouse mutants, dominance and haploinsufficiency, F1 screen, newer screen techniques, genetics of obesity (leptin and MCR gene mutants, cloning process and identification), gene targeting techniques, GWAS study